Original Publications
1.Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. *co-corresponding authors.Cell. Jul. 10, 2009. PMID: 19596240
2. Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer A, and Horng T.A critical role for calcium mobilization in activation of the NLRP3 inflammasome. PNAS. Jul. 10, 2012.PMID: 22733741
3.Byles V*, Covarrubias AJ*, Ben-Sahra I, Lamming D, Sabatini D, Manning B and Horng T.The TSC-mTOR pathway regulates macrophage polarization. *co-first authorship.Nature Communications. Nov. 27, 2013. PMID: 24280772
4.Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM and Horng T.Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. PNAS. Oct. 28, 2014.PMID: 25313054
5. Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Stapornkul TP, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, and Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. eLIFE. Feb. 19, 2016. PMID: 26894960
•Commentary by Torres A et al. Immunometabolism: Metabolism fine-tunes macrophage activation. eLIFE. Feb 19, 2016. PMID: 26894957
6.Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki, Suzuki T, Yamamoto M, Horng T, and Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Science Reports. Aug 18;7(1):8801. PMID: 28821730
7.Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, and Blander JM. Innate sensing of microbial viability orchestrates stress-mediated autophagy of the endoplasmic reticulum. Cell. Nov 2;171(4):809-823. PMID: 29056340
8.P. Kent Langston1, Aya Nambu1, Jonathan Jung1,2, Munehiko Shibata1, H. Ibrahim Aksoylar1, Jiahui Lei1, Peining Xu3, Mary T. Doan3, Helen Jiang3, Michael R. MacArthur1, Xia Gao4, Yong Kong5, Edward T. Chouchani6, Jason W. Locasale4, Nathaniel W. Synder3, and Tiffany Horng1,7* Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature Immunology. 2019 Sep; 20(9):1097-1099. PMID: 31384059.
Reviews and Commentaries
1.Medzhitov R and Horng T*. Transcriptional control of the inflammatory response. *co-corresponding authors.Nature Reviews Immunology. Oct. 2009. PMID: 19859064
2.Horng T and Hotamisligil. Linking the inflammasome to obesity-related disease.Nature Medicine. Feb. 2011. PMID: 21297609
3.Covarrubias A, Byles V, and Horng T. ROS sets the stage for macrophage differentiation.Cell Research. Aug. 2013.PMID: 23835480
4.Kagan JC and Horng T. NLRP3 inflammasome activation:CD36 serves double duty.Nature Immunology. Aug. 2013. PMID: 23867926
5.Horng, T.Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.Trends in Immunology. Jun. 2014. PMID: 24646829
6.Covarrubias AJ and Horng T. IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, Jun. 2014. PMID: 24896536
7.Horng, T. mTOR trains heightened macrophage responses. Trends in Immunology. Jan. 2015. PMID: 25488670
8.Covarrubias AJ, Aksoylar HI and Horng T. Control of macrophage metabolism and activation by mTOR and Akt signaling.Seminars in Immunology. Aug. 2015.
9.Langston PK, Shibata M and Horng T. Metabolism supports macrophage activation.Frontiers in Immunology. Jan. 2017. PMID: 28197151.
10.Olivas J and Horng T. Sugar fuels T cell memory. Nature Cell Biology. Jan. 2018. PMID：29269950.
11.Jung J, Zeng H, and Horng T. Metabolism as a guiding force for immunity. Nature Cell Biology. Jan. 2019. PMID: 30602764.
12.Yan J, Wang R and Horng T. mTOR is Key to T cell Transdifferentiation. Cell Metabolism. Feb. 2019. PMID: 30726756.
13.Yan, Jiawei; Horng, Tiffany. Lipid Metabolism in Regulation of Macrophage Functions.Trends in Cell Biology. Dec 2020. 30(12):979-989. PMID: 33036870
14.Wang, Yafang; Li, Na; Zhang, Xin; Horng, Tiffany. Mitochondrial metabolism regulates macrophage biology. Journal of Biological Chemistry. 01 Jul 2021. 297(1). PMID: 34157289
15.Luan, Haoming; Horng, Tiffany. Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses.Current Opinion in Immunology. 2021. 73. PMID: 34399114